Institutions and Functions

What is an institution? And what distinguishes one type of institution from another? We answer these questions using a functionalist approach: types of institutions are identified by their function, or the coordination problems they solve; token institutions are specific solutions to these problems, or equilibria of strategic games. The functionalist approach provides some insights into the limits of reform, or the extent to which institutions \u2013 like marriage, property, or democracy \u2013 can be modified without turning them into entities of a different kind

Shotgun Proteomics Identifies Serum Fibronectin as a Candidate Diagnostic Biomarker for Inclusion in Future Multiplex Tests for Ectopic Pregnancy

Ectopic pregnancy (EP) is difficult to diagnose early and accurately. Women often present at emergency departments in early pregnancy with a 'pregnancy of unknown location' (PUL), and diagnosis and exclusion of EP is challenging due to a lack of reliable biomarkers. The objective of this study was to identify novel diagnostic biomarkers for EP. Shotgun proteomics, incorporating combinatorial-ligand library pre-fractionation, was used to interrogate pooled sera (n = 40) from women undergoing surgery for EP, termination of viable intrauterine pregnancy and management of non-viable intrauterine pregnancy. Western blot was used to validate results in individual sera. ELISAs were developed to interrogate sera from women with PUL (n = 120). Sera were collected at time of first symptomatic presentation and categorized according to pregnancy outcome. The main outcome measures were differences between groups and area under the receiver operating curve (ROC). Proteomics identified six biomarker candidates. Western blot detected significant differences in levels of two of these candidates. ELISA of sera from second cohort revealed that these differences were only significant for one of these candidates, fibronectin. ROC analysis of ability of fibronectin to discriminate EP from other pregnancy outcomes suggested that fibronectin has diagnostic potential (ROC 0.6439; 95% CI 0.5090 to 0.7788; P>0.05), becoming significant when 'ambiguous' medically managed PUL excluded from analysis (ROC 0.6538; 95% CI 0.5158 to 0.7918; P<0.05). Fibronectin may make a useful adjunct to future multiplex EP diagnostic tests

Science, institutions, and values

This paper articulates and defends three interconnected claims: firstly, that the debate on the role of values for science misses a crucial dimension, the institutional one; secondly, that institutions occupy the intermediate level between scientific activities and values and that they are to be systematically integrated into the analysis; thirdly, that the appraisal of the institutions of science with respect to values should be undertaken within the premises of a comparative approach rather than an ideal approach. Hence, I defend the view that the issue be framed in reference to the following question: “What kind of institutional rules should be in place in order for the scientific process to unfold in such a way that the values that we deem more important come to the fore?” Addressing this concern is equivalent to conducting a debate on institutions and their role for science

A definition of habit for socio-economics

The paper argues that it is a mistake to define habit as behaviour or action; as a regular conjunction of actions; as a stock; as a form of automaticity (although habit is acquired and activated automatically); as a tendency, propensity or disposition (even though habit acts tendentially); as a mechanism; and as a process (even though habit is acquired and activated via several processes). A taxonomic definition is provided wherein habit is a cognitive representation of a cue-action response